Efficacy of low-level laser therapy in the management of neck pain

 METHODS: We searched computerised databases comparing efficacy of LLLT using any wavelength with placebo or with active control in acute or chronic neck pain. 

INTERPRETATION: We show that LLLT reduces pain immediately after treatment in acute neck pain and up to 22 weeks after completion of treatment in patients with chronic neck pain.

https://www.ncbi.nlm.nih.gov/pubmed/19913903/

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Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

 “One of the most general benefits of PBM that has recently emerged, is its pronounced anti-inflammatory effects... The local reduction of edema, and reductions in markers of oxidative stress and pro-inflammatory cytokines are well established. However there also appears to be a systemic effect whereby light delivered to the body, can positively benefit distant tissues and organs. ”  

http://www.aimspress.com/article/10.3934/biophy.2017.3.337

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Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery?

Recently, researchers have shown that phototherapy administered to skeletal muscle immediately before resistance exercise can enhance contractile function, prevent exercise-induced cell damage, and improve postexercise recovery of strength and function. Conclusions: Phototherapy administered before resistance exercise consistently has been found to provide ergogenic and prophylactic benefits to skeletal muscle.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554033/

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Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited

Conclusion: LLLT and LEDT can improve muscle performance, reduce muscle fatigue during exercises and benefit the muscle repair... In this context, we have the best perspectives for patients who have neuromuscular diseases such as Duchenne muscular dystrophy [87]. We believe these patients can be benefited with the power of light of LLLT and LEDT, accelerating muscle repair via satellite cells and decreasing oxidative stress of muscle tissue [88]. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635110/

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Human Brain Reacts to Transcranial Extraocular Light

In conclusion, we have found that extraocular light impacts human brain physiology... Demonstrating how extraocular light influences emotional reactivity might provide additional insights regarding how light directly affects mood [2]. The subtle effect of extraocular light might be critical for healthy human brain functions and disease. Therefore, the results from this study have potential widespread impact on understanding the effect of light on the healthy brain as well as its potential involvement in brain disorders. 

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149525

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Shining light on the head: Photobiomodulation for brain disorders

Parkinson's Disease: Compared with baseline, all participants demonstrated a numerical improvement in the VAS from baseline to study endpoint. A statistically significant reduction in VAS rating for gait and cognitive function was observed with average mean change of —1.87 (p < 0.05) for gait and a mean reduction of —2.22 (p < 0.05) for cognitive function. Further, freezing and difficulty with speech ratings were significantly lower (mean reduction of 1.28 (p < 0.05) for freezing and 2.22 (p < 0.05) for difficulty with speech). 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/

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Photobiomodulation and the brain: a new paradigm

Parkinson's Disease: Consistent across the majority of these studies, though, has been the finding that PBM led to increased levels of tyrosine hydroxylase (TH+), which is itself indicative of improvements in the functioning of dopaminergic cells. The pathology of Parkinson’s disease has also been linked to mitochondrial dysfunction, which has been proven to be counteracted by PBM. Essentially, it seems to be a logical conclusion that PBM could be quite effective in the treatment of Parkinson’s disease in human patients. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448311/

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Transcranial bright light and symptoms of jet lag: a randomized, placebo-controlled trial.

 

RESULTS: We found a significant reduction of overall jet lag symptoms (VAS), subjective sleepiness (KSS), and the fatigue, inertia, and forgetfulness subscales of the POMS when comparing the active TBL treatment group (N = 30) to the placebo group (N = 25). For example, the normalized values of VAS in the TBL, but not the placebo, group returned to pre-travel levels by the final post-travel day (6.16 vs. 15.34).

DISCUSSION: Results suggest a cumulative effect of TBL, as the effects emerged on post-travel days 3-4. Intermittent TBL seems to alleviate jet lag symptoms.

https://www.ncbi.nlm.nih.gov/pubmed/25945550

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Effects of bright light treatment on psychomotor speed in athletes

Conclusion: Psychomotor speed, particularly motor time with a visual warning signal, improves after transcranial bright light treatment in professional ice-hockey players during the competition season in the dark time of the year. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026757/

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Review of transcranial photobiomodulation for major depressive disorder:

There is also clinical preliminary evidence suggesting the efficacy of PBM in treating MDD, and comorbid anxiety disorders, suicidal ideation, and traumatic brain injury. Based on the data collected to date, PBM appears to be a promising treatment for depression that is safe and well-tolerated. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777909/

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Altered resting-state activity in seasonal affective disorder.

SAD patients showed significantly increased functional connectivity in 11 of the 47 identified RSNs. Increased functional connectivity involved RSNs such as visual, sensorimotor, and attentional networks.  

https://www.ncbi.nlm.nih.gov/pubmed/22987670

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Transcranial bright light treatment via the ear canals in seasonal affective disorder:

These results suggests that transcranial bright light treatment may have antidepressant and anxiolytic effect in SAD patients, as both self- and psychiatrist-rated depressive and anxiety symptoms decreased in all treatment groups. These improvements are comparable to findings of earlier bright light studies that used conventional devices 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207317/

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Stimulating brain tissue with bright light alters functional connectivity in brain

The results from the full band resting state ICA dual regression analysis of normal healthy volunteers suggest that brain tissue is inherently light-sensitive. Light stimulation to the brain seems to induce a gradual increase in functional connectivity of the lateral visual network during the course of the stimulus. 

http://file.scirp.org/Html/4-1390047_19417.htm

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Can light treatment via ear canals be effective in relieving symptoms in SAD?

During the study period, 12 out of 13 (92.3%) patients achieved at least 50% reduction in their HAMA sum scores, and in 10 out of 13 patients (76.9%), 

https://www.ncbi.nlm.nih.gov/pubmed/22296809

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Light therapy for better mood & insulin sensitivity in patients with major depression & diabetes II

Major depression and concurrent sleep disorders have been related to disturbances of the biological clock. The biological clock is also involved in regulation of glucose metabolism by modulating peripheral insulin sensitivity. Light therapy has been shown to be an effective antidepressant that ‘resets’ the biological clock. We here describe the protocol of a study that evaluates the hypothesis that light therapy improves mood as well as insulin sensitivity in patients with a major depressive episode and type 2 diabetes. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513382/

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Is light-emitting diode phototherapy (LED-LLLT) really effective?

 A large variety of cytokines, chemokines and macromolecules can be induced by LED phototherapy. Among the clinical applications, non-healing wounds can be healed through restoring the collagenesis/collagenase imbalance in such examples, and ‘normal’ wounds heal faster and better. Pain, including postoperative pain, postoperative edema and many types of inflammation can be significantly reduced. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799034/

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A Preliminary Study of the Safety of Red Light Phototherapy of Tissues Harboring Cancer

Objective: Red light phototherapy is known to stimulate cell proliferation in wound healing. This study investigated whether low-level light therapy (LLLT) would promote tumor growth when pre-existing malignancy is present. Results: Daily tumor measurements demonstrated no measurable effect of LLLT on tumor growth. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423866/

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What is Red Light Therapy?

Red light therapy uses low-energy light emitting diodes (LEDs) or lasers to improve celullar function.

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How Does Red Light Therapy Decrease Inflammation?

Researchers have concluded that red light resets the mitochondria in your blood to function properly, produce anti-inflammatory proteins, anti-oxidants, and energy, and to detoxify your body. When inflammation is reduced, a wide range of body and brain functions are improved. Memory and cognitive skills function better when there is less inflammation in the brain. Many disorders and diseases are caused by or significantly worsened by inflammation.

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